David Chartier at Macworld has some great tips on how to manage the firehose of information that Twitter can become, depending on who you’re following.
The first step is to choose your Twitter clients carefully. I recently switched to Tweetbot on my iPhone and iPad and have really enjoyed them so far. Gorgeous interface, very easy to send interesting links to Instapaper, and excellent Readability integration.
On my Mac, I’m still using Twitterific simply because it’s been the only Mac client that supports Tweet Marker for keeping my place in my timeline. Until recently, that is, because Osfoora was just released for Mac, iPhone, and iPad. Looks promising, but I’m not jumping ship yet.
For Windows, TweetDeck is still the way to go.
And of course, feel free to follow me on Twitter.